Resource Type

Journal Article 375

Conference Videos 155

Conference Information 2

Conference Topics 1

Year

2024 2

2023 41

2022 71

2021 146

2020 45

2019 37

2018 20

2017 24

2016 21

2015 17

2014 18

2013 15

2012 16

2011 10

2010 9

2009 9

2008 10

2007 13

2006 3

2005 1

open ︾

Keywords

HZSM-5 6

2 5

5G 5

1 3

optimization 3

5-hydroxymethylfurfural 2

Triticum aestivum 2

ANOVA 2

Additive manufacturing 2

Artificial intelligence 2

CFR dams 2

CO2 2

Hepatocellular carcinoma 2

Machine learning 2

Massive MIMO 2

Vaccine 2

aromatics 2

cancer therapy 2

concrete face 2

open ︾

Search scope:

排序： Display mode:

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: , impaired autophagy was observed, as shown by a decreased LC3II/LC3I protein ratio and an elevated P62Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagyNotably, miR-193-5p overexpression decreased plaque size and increased collagen content.In conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10Thus, miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

HTML PDF Collect

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 642-650 doi: 10.1007/s11684-019-0719-3

Abstract: This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinineCirculating miR-154-5p, inflammatory (C-reactive protein (CRP); erythrocyte sedimentation rate (ESR);UACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESRElevated levels of UACR and miR-154-5p were directly correlated with HbA1c, sCr, BUN, ESR, CRP, VEGF,These findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in

Keywords： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

HTML PDF Collect

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

HTML PDF Collect

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: -5p are still unknown.Moreover, RGS16 was validated as a direct target gene of miR let-7c-5p.The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking downmiR let-7c-5p had the opposite effect.Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

HTML PDF Collect

MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 331-343 doi: 10.1007/s11684-015-0409-8

Abstract: In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3p and miR-142-5p were significantlyOverexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression ofboth synergistically inhibited cell migration, which indicated that miR-142-3p and miR-142-5p may cooperativelyregulate cell movement. miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3′miR-142-5p with several cell motility-associated pathways, including those regulating actin cytoskeleton

Keywords： hepatocellular carcinoma     microRNA     metastasis     cytoskeletal reorganization    

HTML PDF Collect

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: In our study, we found by qRT-PCR that miR-148b was significantly upregulated in sheep wool follicleOverexpression of miR-148b promoted proliferation of both HHDPC and HHGMC.Furthermore, transcript factor nuclear factor of activated T cells type 5 ( ) and were predicted tobe the target of miR-148b and this was substantiated using a Dual-Luciferase reporter system.Subsequently was further identified as the target of miR-148b using western blotting.

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

HTML PDF Collect

The microRNA, miR-29c, participates in muscle development through targeting the

Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 311-317 doi: 10.15302/J-FASE-2015075

Abstract: Previous studies indicated that miR-29c is important for muscle development in mice and human, but itsIn this study, we detected the expression of miR-29c in Meishan longissimus lumborum (LL) muscle.The results showed that miR-29c was gradually upregulated during development of skeletal muscle in pigMoreover, the expression of and genes, which were confirmed to be targeted by miR-29c in mice, wasAlso, the luciferase assay indicated that miR-29s can target the gene in pigs.

Keywords： pig     miR-29c     skeletal muscle     expression     SNP    

HTML PDF Collect

Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 456-463 doi: 10.1007/s11684-014-0353-z

Abstract: <p>microRNAs (miRNAs) have played a key role in human tumorigenesis, tumor progression, and metastasisIn this study, Du145 cells were transfected with miR-200c mimics or negative control miR-NC by usingThe relative expression of miR-200c was measured by RT-PCR.likewise, miR-200c could inhibit migration and invasion by epithelial-mesenchymal transition.p>

Keywords： miR-200c     proliferation     migration     invasion     prostate cancer     Du145 cell     ZEB1    

HTML PDF Collect

The expression mode of hsa-miR-197 in uterine leiomyomas tissue and related bioinformatics analysis

Xu Qing,Fu Ziyi,Wu Xiaoli,Huangfu Yushuang and Ling Jing

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 99-104

Abstract: <p style="text-align: justify;">We performed Real-time PCR to detect the hsa-miR-197 expression levelsmiRbase，UCSC，NCBI are employed to analysis the sequence conservation and genetic characteristics of hsa- miR- 197；miRNA databases such as miRanda，MirTarget2 and TargetScan are chosen to predict hsa- miR- 197 target-197 playing in regulating the uterine leiomyomas occurrence and development. hsa-miR-197 functions inp>

Keywords： uterine leiomyomas     hsa-miR-197     bioinformatics analysis     target genes    

HTML PDF Collect

Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 214-222 doi: 10.1007/s11684-017-0518-7

Abstract: <p>MicroRNAs (miRNAs) play critical roles in the development and progression in various cancers.Dysfunctional miR-9 expression remains ambiguous, and no consensus on the metastatic progression of ovarianLuciferase reporter assay results confirmed that miR-9 could directly target this 3′-UTR. miR-9could be effectively inhibited via miR-9 inhibitor.p>

Keywords： ovarian cancer     metastasis     miR-9     E-cadherin    

HTML PDF Collect

-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Chunyan Gu,Xichao Yu,Xiaozhu Tang,Leilei Gong,Jingquan Tan,Yuanjiao Zhang,Huili Zheng,Ze Wang,Chenqian Zhang,Yejin Zhu,Zuojian Zhou,Heming Yu,Kai Xu,Jinao Duan,Xiaosong Gu,Ye Yang,

Engineering doi: 10.1016/j.eng.2023.09.007

Abstract: Illumina deep sequencing analysis and stem-loop polymerase chain reaction (PCR) assay revealed that miR162aImmunofluorescence staining showed that miR162a was absorbed through systemic RNA interference defectiveBioinformatics prediction and luciferase reporter assay identified that miR162a targeted nuclear receptorAlizarin red staining and micro-computed tomography (microCT) confirmed that miR162a promoted osteogenicIn addition, transgenic Nicotiana benthamiana (N. benthamiana) leaves overexpressing miR162a were developed

Keywords： Traditional Chinese medicine     Lycium barbarum     L     miR162a     Osteoporosis     Nuclear receptor corepressor     Transgenic    

HTML PDF Collect

MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Tao Rui,Xueyou Zhang,Shi Feng,Haitao Huang,Shaowei Zhan,Haiyang Xie,Lin Zhou,Shusen Zheng,Qi Ling,

Engineering 2022, Volume 16, Issue 9,   Pages 162-175 doi: 10.1016/j.eng.2021.07.020

Abstract: In the current study, we aim to explore the role of miR-516a-3p—an identical mature microRNA (miRNAHigh expression of tumor miR-516a-3p significantly correlated with advanced tumor stages, distinguishedWe further found that miR-516a-3p enhanced the proliferation, migration, and invasiveness of HCC cells-516a-3p and as central players in miR-516a-3p-mediated metabolism regulation.Thus, we suggest miR-516a-3p as a novel molecular target for HCC therapy.p>

Keywords： Hepatocellular carcinoma     miRNA cluster     Exosome     Multi-omics    

HTML PDF Collect

Estimation of flexible pavement structural capacity using machine learning techniques

Nader KARBALLAEEZADEH, Hosein GHASEMZADEH TEHRANI, Danial MOHAMMADZADEH SHADMEHRI, Shahaboddin SHAMSHIRBAND

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 5,   Pages 1083-1096 doi: 10.1007/s11709-020-0654-z

Abstract: In this study, three machine learning methods entitled Gaussian process regression, M5P model tree, and

Keywords： transportation infrastructure     flexible pavement     structural number prediction     Gaussian process regression     M5P    

HTML PDF Collect

Preparation of P

Wenjiang LI, Fei XIE, Dongxu HUA, Chunli ZHANG, Chen DAI, Zhenyun YU, Meizhou QI, Shaojun YU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 314-317 doi: 10.1007/s11705-010-0573-y

Abstract: tetraethoxysilane (TEOS) as the precursor for the SiO and phosphoric acid (H PO ) as the precursor for PThe hollow structure of the P O -SiO (silicophosphate) was characterized by X-ray diffraction (XRD),

Keywords： P2O5-SiO2     hollow microspheres     sol-gel/emulsion     phosphoric acid    

HTML PDF Collect

Title Author Date Type Operation

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Journal Article

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

The microRNA, miR-29c, participates in muscle development through targeting the

Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI

Journal Article

Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Journal Article

The expression mode of hsa-miR-197 in uterine leiomyomas tissue and related bioinformatics analysis

Xu Qing,Fu Ziyi,Wu Xiaoli,Huangfu Yushuang and Ling Jing

Journal Article

Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Journal Article

-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation

Chunyan Gu,Xichao Yu,Xiaozhu Tang,Leilei Gong,Jingquan Tan,Yuanjiao Zhang,Huili Zheng,Ze Wang,Chenqian Zhang,Yejin Zhu,Zuojian Zhou,Heming Yu,Kai Xu,Jinao Duan,Xiaosong Gu,Ye Yang,

Journal Article

MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Tao Rui,Xueyou Zhang,Shi Feng,Haitao Huang,Shaowei Zhan,Haiyang Xie,Lin Zhou,Shusen Zheng,Qi Ling,

Journal Article

Estimation of flexible pavement structural capacity using machine learning techniques

Nader KARBALLAEEZADEH, Hosein GHASEMZADEH TEHRANI, Danial MOHAMMADZADEH SHADMEHRI, Shahaboddin SHAMSHIRBAND

Journal Article

Preparation of P

Wenjiang LI, Fei XIE, Dongxu HUA, Chunli ZHANG, Chen DAI, Zhenyun YU, Meizhou QI, Shaojun YU

Journal Article

construction integration technology in Brazil’s superlarge deep-water offshore oil and gas unit project (FPSO P67/P70)

Journal Article